Memphis has a mid-latitude, moist continental climate, which means it has four distinct seasons with cold winters and hot summers. Spring and autumn can be varied and unpredictable and severe weather, like thunderstorms and strong winds, are possible during these transitory seasons. Summers are very humid thanks to moisture encroaching from the Gulf of Mexico, even though the temperature rarely reaches great heights. This makes it feel hotter than it is. Winters, by contrast, can be very cold with temperatures below freezing occurring fairly often. Memphis averages 5.7 inches of snow a year. There is plenty of rain to keep the region green, most falling in thunderstorms, but this does not mean there are not plenty of sunny days. Memphis has sun for 64% of its days, which it proudly claims adds up to more sunny days annually than are experienced in Miami.

As most residents own a car, public transport is not very reliable and the most efficient way to cover the sprawling city is by car, although traffic congestion can make it slow, even more so during rush hours. The city is simple to navigate and parking is generally easy to find. To hire a car drivers must be 21 years old, but most agencies have higher rates for under-25s; some require an International Driving Permit as well as a valid driver's license. Public transport is available, but consists of slow and infrequent buses, as well as the more useful Main Street Trolley that covers downtown in a circular route. Taxis are also available and must be booked by phone.

English is the most common language but Spanish is often spoken in south-western states.

The US Dollar (USD) is the unit of currency and is divided into 100 cents. Only major banks exchange foreign currency. ATMs are widespread and credit cards and travellers cheques are widely accepted. Travellers cheques should be taken in US Dollars to avoid hassles. Banking hours are Monday to Friday 9am to 3pm.